Effects of toxic substances on female reproduction

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Effects of toxic substances on female reproduction

Successful reproduction requires a complex series of interdependent physiological, cellular and molecular events. In the female many of these interdependent events are vulnerable to interruption by xenobiotic compounds. The physiological steps in the female reproductive cycle are reviewed. Selected xenobiotics which interrupt this cycle are presented and their mechanisms and site of adverse eff...

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Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction.

STUDY QUESTION Does prenatal exposure to perfluoroalkyl substances (PFASs) have long-term effects on female reproductive function?. SUMMARY ANSWER Our results suggest an association between in utero exposure to perfluorooctanoic acid (PFOA) and delay in age of menarche. WHAT IS KNOWN ALREADY Previous cross-sectional studies have reported possible effects of PFASs on female reproduction incl...

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Factors influencing reproduction and genetic toxic effects on male gonads

The objective of toxicological study of a target organ, such as the testis, is to elucidate the qualitative and quantitative toxic effects of a chemical on that organ. The ultimate objective is to assess the toxic effects of a chemical in laboratory animals and extrapolate the pertinent experimental data to man. To accomplish these objectives, one must consider the main factors which may influe...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1983

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.834843